Solifenacin Intermediates
Somu Organo-Chem Pvt.
Ltd was established in the year 1995 with a manufacturing unit at Malur near
Bangalore to manufacture Speciality Fine Chemicals, Pharma Intermediates,
Perfumery and flavour Intermediates, Agro Chemical Intermediates, Mining
Chemicals and Flotation Reagents.
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| Solifenacin Intermediates |
Solifenacin, marketed
as solifenacin succinate under the trade name Vesicare, is a urinary
antispasmodic of the anticholinergic class. It is used in the treatment of
overactive bladder with urge incontinence.
Solifenacin is
contraindicated for people with urinary retention, gastric retention,
uncontrolled or poorly controlled closed-angle glaucoma, severe liver disease.
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| Solifenacin Intermediates |
Side effects
The most common side
effects of solifenacin are dry mouth, blurred vision, and constipation. As all
anticholinergics, solifenacin may rarely cause hyperthermia due to decreased
perspiration.
Solifenacin is metabolized
in the liver by the cytochrome P450 enzyme CYP3A4. When administered
concomitantly with drugs that inhibit CYP3A4, such as ketoconazole, the
metabolism of solifenacin is impaired, leading to an increase in its
concentration in the body and a reduction in its excretion.
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| Solifenacin Intermediates |
Mechanism of action
Solifenacin is a
competitive cholinergic receptor antagonist, selective for the M3
receptor subtype. The binding of acetylcholine to these receptors, particularly
M3, plays a critical role in the contraction of smooth muscle. By
preventing the binding of acetylcholine to these receptors, solifenacin reduces
smooth muscle tone in the bladder, allowing the bladder to retain larger
volumes of urine and reducing the number of micturition, urgency and incontinence
episodes. Because of a long elimination half life, a once-a-day dose can offer
24-hour control of the urinary bladder smooth muscle tone.
What
we do
Somu Organo-Chem Pvt.
Ltd are specialized in Manufacturing Pharma Intermediates and Speciality
Chemicals based on Hydrogenation Process under high pressure, mainly import
substitute products that are poised for tremendous growth in the years to come.
We are also specialized in Esterification, Extraction and Distillation
processes under which we are Manufacturing Specialty Solvents to cater to
paint, Coating, Ink, electronic and Pharmaceutical Industries.
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| Solifenacin Intermediates |
Our Policy
- Deliver Quality Products and Services to our Customers.
- Treat Customers as our Partners.
- To be Environment and Society Conscious.
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